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KMID : 0370920110280010001
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Yeungnam Univercity Journal of Medicine
2011 Volume.28 No. 1 p.1 ~ p.12
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Combined Hepatocellular-Cholangiocarcinoma: Recent Progress in Pathology and Classification
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Choi Joon-Hyuk
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Abstract
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Primary liver carcinomas have been classified into hepatocellular carcinoma, cholangiocarcinoma, and combined hepatocellular-cholangiocarcinoma (CHC). CHC is a tumor containing unequivocal, intimately mixed elements of both hepatocellular carcinoma and cholangiocarcinoma. It forms a small but significant proportion of primary liver carcinomas. The origin and pathogenesis of CHC have not been well established. According to the 2010 WHO classification, CHCs are categorized into 2 groups: the classical type and a subtype with stem cellfeatures. This review describes recent progress in pathology and classification of CHC.
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KEYWORD
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Liver, Combined hepatocellular-cholangiocarcinoma, Immunohistochemistry, Stem cell, Classificatio
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